Ozempic Weight Loss and Loose Skin: What to Expect and How to Treat It

If you’ve been taking Ozempic for weight loss, you’ve probably noticed the number on the scale dropping—sometimes dramatically. This prescription medication, originally designed for managing blood sugar levels in people with type 2 diabetes, has gained massive popularity for its ability to help with chronic weight management. But while shedding excess weight can be life-changing, one of the unexpected side effects for many people is loose skin.

From sagging jowls (aka “Ozempic face”) to excess skin on the upper arms, abdomen, and thighs, many who lose weight quickly with weight loss drugs like Ozempic are left wondering: Can anything be done about loose skin? And is it possible to prevent it in the first place?

Ahead, we dive into why loose skin occurs after significant weight loss, what factors influence skin elasticity, and how to treat sagging skin—both non-surgically and through plastic surgery.

Why Does Ozempic Cause Loose Skin?

Loose skin after weight loss isn’t exclusive to weight loss injections like Ozempic—it can happen with other weight loss medications, bariatric surgery, or even traditional diet and exercise. But Ozempic, Wegovy, and similar drugs often lead to rapid weight loss, which can affect skin elasticity more than gradual weight loss does.

Here’s why:

Skin stretches with weight gain. When we gain weight, our skin expands to accommodate excess fat. The longer it stays stretched, the harder it becomes to bounce back.

Collagen and elastin play a major role. These proteins give skin its structure and elasticity. As we age, our collagen production decreases, making it harder for skin to “snap back.”

Losing weight quickly can make it worse. The faster you lose weight, the less time your skin has to adjust, leading to a hollowed appearance or sagging skin, especially in the face and neck area.

How Much Weight Loss Leads to Loose Skin?

Not everyone who takes Ozempic will experience loose skin, but certain factors play a significant role in whether your skin will bounce back or remain stretched after significant weight loss. While some people maintain enough skin elasticity for their skin to retract naturally, others may struggle with excess skin that doesn’t shrink even after they’ve reached their goal body weight.

So, how much weight loss is too much when it comes to skin laxity? Generally, people who lose 50 pounds or more—especially over a short period—are more likely to notice sagging skin, particularly in areas like the abdomen, upper arms, thighs, and neck.

Factors that affect loose skin after weight loss include:

1. Amount of Weight Lost

The more excess weight you shed, the more your skin has to adjust. Losing 10 to 20 pounds may not cause noticeable loose skin, but losing 50+ pounds often leads to excess skin folds that won’t tighten up on their own. Massive weight loss (100 pounds or more) typically results in loose skin that requires either non-surgical skin tightening treatments or plastic surgery for removal.

2. Age

Younger skin contains more collagen and elastin, which allows it to contract better after fat loss. If you lose weight in your 20s or early 30s, your skin has a better chance of snapping back compared to someone in their 40s or 50s, when collagen production declines. As a result, older individuals are more likely to experience facial sagging, hollowed cheeks, and a gaunt appearance after weight loss.

3. Genetics

Just like some people naturally have firm, elastic skin, others are predisposed to sagging jowls and loose skin after weight loss. Your genetic makeup determines how well your skin bounces back and how much collagen production slows down as you age.

4. How Long You Carried Excess Weight

If you were overweight or obese for many years, your skin’s elasticity has likely weakened, making it harder for it to shrink back. The longer your skin remains stretched, the less likely it is to fully tighten after losing weight.

5. Rate of Weight Loss

While rapid weight loss is often seen as a good thing, losing too much weight too fast can leave you with excess skin. When you lose weight quickly—whether through weight loss medications, Ozempic, bariatric surgery, or extreme dieting—your skin doesn’t have time to gradually adjust to your new body shape. Slower weight loss allows your skin tissue to keep up with your body fat reduction, potentially reducing the severity of loose skin.

Can Loose Skin Be Prevented While Losing Weight?

While there’s no foolproof way to completely prevent loose skin, there are ways to improve skin elasticity and minimize sagging while losing weight. The key is to focus on gradual weight loss, muscle retention, and skin health.

1. Prioritize Strength Training

One of the best ways to combat loose skin is to replace lost fat tissue with muscle mass. When you build muscle, it helps fill out your skin, reducing the appearance of excess skin. Strength training can be particularly helpful for areas prone to sagging, such as the arms, thighs, and abdomen.

Aim for resistance training at least three to four times a week, focusing on compound movements like squats, lunges, push-ups, and deadlifts. This not only supports skin tightening but also helps shape your new body after losing weight.

2. Stay Hydrated

Hydration is essential for collagen production and skin elasticity. When skin is dehydrated, it loses its ability to snap back, making sagging skin more pronounced. Drinking at least 8 to 10 glasses of water daily helps keep skin cells plump, improving the overall appearance of loose skin.

3. Focus on Nutrition

What you eat plays a major role in skin health. Prioritize nutrient-dense foods that support collagen production and skin repair:

Collagen peptides – Found in bone broth, fish, and collagen supplements, these help maintain skin elasticity.

Hyaluronic acid – Found in leafy greens and soy-based foods, this keeps skin hydrated and plump.

Vitamin C & E – Both are essential for collagen synthesis and can be found in citrus fruits, bell peppers, almonds, and avocados.

Protein-rich foods – Lean meats, eggs, and legumes support muscle retention, which helps prevent hollowed-out areas and loose skin.

4. Lose Weight Gradually

If you’re using Ozempic or other weight loss medications, work with your doctor to set realistic weight loss goals. Aim to lose no more than 1 to 2 pounds per week, which allows your skin tissue to gradually adjust and reduces the risk of excess skin.

Non-Surgical Treatments for Loose Skin

If you’re dealing with moderate sagging but aren’t ready for plastic surgery, non-invasive and minimally invasive treatments can help tighten loose skin and restore a youthful appearance.

1. Topical Skincare

While skincare alone won’t reverse excess skin, certain ingredients can support skin elasticity and collagen production. Look for:

Retinol – Encourages cell turnover and boosts collagen levels.

Vitamin C serums – Help brighten facial skin and improve firmness.

Hyaluronic acid – Hydrates skin and adds plumpness to areas with lost volume.

2. Skin-Tightening Procedures

For those wanting noticeable results without surgical procedures, these options can help:

Ultrasound Therapy (Ultherapy) – Uses sound waves to tighten skin on the face and neck area.

Microneedling (SkinPen) – Stimulates collagen and elastin production.

Laser Skin Tightening – Improves skin tone and elasticity over multiple sessions.

3. Dermal Fillers & Fat Grafting

For those experiencing facial sagging or a hollowed appearance, injectables can help restore facial fullness:

Hyaluronic acid dermal fillers – Add volume to cheeks and jawline.

Sculptra – Helps stimulate the body’s natural collagen production, producing results that are natural and long lasting.

Fat grafting – Transfers fat cells from one part of the body to another for natural volume restoration.

Surgical Options for Loose Skin Removal

For those experiencing severe loose skin after massive weight loss, plastic surgery may be the most effective way to achieve a more sculpted, toned appearance. While non-surgical skin tightening treatments can help with mild skin laxity, individuals with significant excess skin may require surgical procedures to remove it permanently.

Here’s a closer look at the surgical options available:

1. Tummy Tuck (Abdominoplasty)

A tummy tuck is one of the most popular procedures for individuals who have lost a significant amount of weight, especially after taking Ozempic or undergoing bariatric surgery. This surgery removes excess abdominal skin and tightens the underlying muscles, resulting in a flatter, more toned stomach.

2. Arm Lift (Brachioplasty)

After rapid weight loss, many people develop loose skin on the upper arms, sometimes called “bat wings.” An arm lift (brachioplasty) removes excess skin from the upper arms, giving them a firmer, more toned look.

3. Neck Lift & Deep Plane Facelift

One of the most talked-about side effects of losing weight quickly with Ozempic and other weight loss medications is facial sagging, often referred to as “Ozempic face.” This happens when facial fat is lost too quickly, leading to a gaunt, hollowed-out appearance. A neck lift and deep plane facelift can help restore facial fullness while tightening the face and neck area.

4. Body Contouring Procedures

For individuals with loose skin in multiple areas, a full body lift or body contouring surgery may be the best approach. This involves a combination of skin removal procedures, such as a posterior body lift with buttock auto-augmentation, tummy tuck, thigh lift, arm lift, and breast lift, tailored to the patient’s specific needs.

When to See a Professional

If your loose skin is causing discomfort, rashes, or self-consciousness, it may be time to consult with a plastic surgeon or dermatologist. Consider seeing a professional if:

Your loose skin occurs in multiple areas and won’t tighten with lifestyle changes

You’re experiencing skin irritation or infections from excess skin folds

You feel self-conscious about your facial appearance or body shape

You’re interested in cosmetic treatments with minimal downtime

Final Thoughts

Losing weight with Ozempic can be empowering, but it’s important to be aware of the potential for loose skin—especially if you lose weight quickly. While diet and exercise can improve skin elasticity, non-surgical treatments, and plastic surgery, options can help treat Ozempic face, tighten sagging skin, and restore a more youthful appearance.

If loose skin is a concern, speaking with a board-certified plastic surgeon can help you explore your options and decide what’s best for your body weight and lifestyle.

Would you consider a skin-tightening procedure or surgical intervention after major weight loss? Let us know in the comments!

The post Ozempic Weight Loss and Loose Skin: What to Expect and How to Treat It appeared first on Dr. Sam Sukkar MD | The Clinic for Plastic Surgery.